Dilated cardiomyopathy
is a clinical condition in which primarily heart’s left ventricular considered
to be the main pumping chamber is affected where it becomes enlarged unable to
pump blood to the body. If proper measures are not taken then the problem often
spreads to the right ventricle and then to the atria as the disease gets worse.
Dilated cardiomyopathy also can lead to heart valve problems, arrhythmias
(irregular heartbeats) and blood clots in the heart.Dilated cardiomyopathy may
affect people of all ages, including infants and children. The treatments
available especially focus on underlying cause of dilated cardiomyopathy, to
improve blood flow and reduce other symptoms. Dilated cardiomyopathy’s drug
therapy includes Angiotensin-converting enzyme (ACE) inhibitors, Angiotensin II
receptor blockers, beta blockers, diuretics, Aldosterone antagonists, digitalis
and anticoagulants. While implantable devices used to treat dilated
cardiomyopathy includes biventricular pacemakers, implantable
cardioverter-defibrillators (ICDs) and heart pumps (left ventricular assist
devices).
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The major causes of dilated cardiomyopathy are genetics, birth defects,
infections, drug and alcohol abuse, certain cancer medications and exposure to
toxins like lead, mercury and cobalt. In case of dilated cardiomyopathy, male
patients are more prone to it than female patients, ratio is approximately 3:1.
According to American Stroke Association, dilated cardiomyopathy is the most
common form of cardiomyopathy and accounts for approximately 55 to 60% of all
childhood cardiomyopathies. According to the pediatric cardiomyopathy registry
database, this form of myopathy is detected in roughly 1 to 2 per 200,000
children with roughly one new case per 160,000 children reported each year in
the United States.
The companies involved in the dilated cardiomyopathy therapeutics
clinical trials areAastrom Biosciences, Inc., t2cure GmbH, Zensun (Shanghai)
Sci& Tech Co., Ltd., Kasiak Research Pvt. Ltd., MyoKardia, Inc. and
Capricor Therapeutics, Inc.
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