Multiple
sclerosis (MS) is an inflammation of fatty myelin sheaths around the axons of
the brain and spinal cord. MS tends to affect the ability of nerve cells to communicate
with each other in the brain and spinal cord. MS affects people with random
symptoms based on the location and severity of attack. One event can last for
days, weeks or months and can affect any part of the body. Symptoms include
imbalance, loss of motor function, spasms, numbness, incontinence, and
difficulty in swallowing.
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There is no known cure
for the disease currently and the only drugs available in the market are for
delaying the progression of the disease. MS is estimated to affect 2.5 million
people worldwide with around 5000 new cases developing each year. The National
Multiple Sclerosis Society, Multiple Sclerosis Foundation, Multiple Sclerosis
Association of America and several others are organizations which are
determined to ensure improvement in the lives of affected people to make them
more educated and spread awareness of this disease.
Until the last year,
the MS drugs market was led primarily by injectables, yet this trend is
changing very quickly to give way to oral MS drugs which is expected to grow
strongly beginning from 2013. Gilenya and Aubagio are the top current oral
drugs in this segment and Biogen’s oral BG-12 and Teva Laquinimod are two other
drugs in the pipeline for approval with a significantly higher efficacy to be
launched in the next five years. Although oral MS drugs seem to be growing
quickly, it is not expected that they would unsettle injectables anytime soon.
Several fatal side effects have been linked to use of Gilenya among those who
have a heart disease and thus shows that there is still a long way to go for
oral MS drugs. Top contenders in this segment till now are Copaxone, Avonex,
Rebif, Betaseron, and Tysabri. Most of these drugs work actively to control MS
relapses. Other treatments such as stem-cell transplantation are currently
under investigation. The process includes the injection of stem cells which
will replace the affected inflamed and diseased cells, greatly improving
patient’s quality of life.
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