Muckle-Wells Syndrome (MWS) is a rare, genetic autosomal disease which
leads to urticaria, sensorineural deafness, and also leads to amyloidosis. The
disease is mainly caused due to mutation of CIAS1 gene, that leads to increased
production of interleukin 1B. Due to interaction of IL1B and skin receptors,
the inflammation occurs, which leads to fever and rashes. The common symptoms
include fevers, chills, deafness, arthritis, and recurrent urticaria.The episode
of MWS usually lasts for around 48 hours. The disease belongs to a family of
cryopyrin- associated periodic syndromes (CAPS), including 2 other diseases,
caused by mutation of CIAS1 gene.
Muckle-Wells Syndrome can be diagnosed with the help of study of
patient’s symptoms and medical evaluation. In addition, gene testing and NLRP3
mutation study also helps in diagnosis of the disease. Owing to extensive
growth in genetic engineering, the market is expected to grow duringthe
forecast period 2013 to 2019. The major treatments for MWS includes Rilonacept
(for CAPS treatment), anakinra (IL-1 receptor antagonist) and Canakinumab, a
monoclonal antibody. In addition to the existing treatments, some new
treatments are under pipeline studies.
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The market of Muckle-Wells Syndrome is driven by factors such as,
extensive R&D activities, technological advancement in research and genetic
sciences and growing concern about various genetic disorders. Extensive R&D
is one of the major factor, propelling the market growth. Considering the
growth perspective, many pharmaceutical and biotechnological leaders are
engaged in the development of medications and treatments for this disease.
However, low epidemiology, lack of awareness and high cost of R&D and
treatment are some of the restraints, expected to impose a threat to the growth
of the market.
Some of the major players engaged in development and commercialization of
treatments for Muckle-Wells Syndrome includes Novartis AG, Istituto Giannina
Gaslini, Regeneron Pharmaceuticals, Inc. and Charite-Universitatsmedizin Berlin
amongst others.
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